How the microenvironment shapes intracellular chlamydial infection and pathogenicity

Principal Investigator

Prof. Dr. med.

Associated Doctoral Researcher

Background and current state of research

In this project, we will investigate the impact of different environmental factors on intracellular C. trachomatis infection in primary fallopian tube epithelial cells and a recently established ex-vivo primary fallopian tube model. It is known that a low oxygen environment dramatically changes metabolic activity and IFN-g induced persistence of chlamydiae.

Our goals

Based on preliminary results from an epidemiological microbiota study in infertile women we will particularly focus on the influence on co-infections with other bacteria such as Ureaplasma sp. and Snaethia sp. on the chlamydial developmental cycle and chlamydia  induced inflammatory pathways.

This project is related to project 4: "Influence of the microenvironment on the pathogenicity of C. trachomatis in ascending genital tract infections in females".