Publications

Here you will find all publications which arise during the work of our doctoral researchers within the RTG. But before the first steps into research have to be done.
Overview of methodologies for T-cell receptor repertoire analysis.
Rosati, E., Dowds, C.M., Liaskou, E., Henriksen, E.K.K., Karlsen, T.H., Franke, A.
(2017)
Overview of methodologies for T-cell receptor repertoire analysis.
BMC Biotechnology
Jul 10;17(1):61:
Hypothalamic Inflammation in Human Obesity is Mediated by Environmental and Genetic Factors.
Kreutzer C, Peters S, Schulte DM, Fangmann D, Türk K, Wolff S, van Eimeren T, Ahrens M, Beckmann J, Schafmayer C, Becker T, Kerby T, Rohr A, Riedel C, Heinsen FA, Degenhardt F, Franke A, Rosenstiel P, Zubek N, Henning C, Freitag-Wolf S, Dempfle A, Psilopa
(2017)
Hypothalamic Inflammation in Human Obesity is Mediated by Environmental and Genetic Factors.
Diabetes
epub ahead of print:
Quantitative Trait Locus Analysis Implicates CD4+/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
Bischof J., Müller S., Borufka L., Asghari F., Möller S., Holzhüter SA., Nizze H., Ibrahim SM., Jaster R.
(2015)
Quantitative Trait Locus Analysis Implicates CD4+/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
PLoS One
Sept 1:
10(9)
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB3, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, ......Ron D, Rosenstiel P, Blumberg RS, Kaser A.
(2017)
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
J. Exp. Med.
Jan 12:
epub ahead of print
TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M
Maria Henström, Fatemeh Hadizadeh, Arthur Beyder, Ferdinando Bonfiglio, Tenghao Zheng, Ghazaleh Assadi, Joseph Rafter, Luis Bujanda, Lars Agreus, Anna Andreasson, ..... Gianrico Farrugia, Mauro D'Amato
(2016)
TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M
Gut
14 Dec.:
epub ahead of print
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
Speck, Reiss
(2015)
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
Journal of biological chemistry
Mar 20; 290(12):
7416-25
Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation
Speck, Reiss, Huebbe, Rimbach
(2014)
Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation
Free Radic Biol Med
May;70:
255-64
A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
Hadizadeh
(2016)
A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
Gut
Jul 29:
Stool frequency is associated with gut microbiota composition
Fatemeh Hadizadeh, Meriem Belheouane, Femke-Anouska Heinsen
(2016)
Stool frequency is associated with gut microbiota composition
Gut
Ap 28:
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz
(2016)
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Nat Genet.
Nov;48(11):
1396-1406
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
Konrad Aden, Alexandra Breuer, Ateequr Rehman, Helene Geese, Florian Tran, Jan Sommer, Georg H. Waetzig, Torsten M. Reinheimer, Stefan Schreiber, Stefan Rose-John, Jürgen Scheller and Philip Rosenstiel
(2016)
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
Oncogene
Nov 21:
5(11):e270.
bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data
Bischof J, Ibrahim S.
(2016)
bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data
PLoS One
Aug 23;11(8):
:e0161569
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Tschurtschenthaler M, Kachroo P, Heinsen FA, Adolph TE, Rühlemann MC, Klughammer J, Offner FA, Ammerpohl O, Krueger F, Smallwood S, Szymczak S, Kaser A, Franke A.
(2016)
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Sci Rep.
6 / Aug 19:
31640
APOE gentotype and stress response – a mini review
Janina Dose, Patricia Huebbe, Almut Nebel, Gerald Rimbach.
(2016)
APOE gentotype and stress response – a mini review
Lipids in Health and Disease
Jul 25:
15:121
Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation
Konrad Aden, Ateequr Rehman, Maren Falk-Paulsen, Thomas Secher, Jan Kuiper, Florian Tran, Steffen Pfeuffer, Raheleh Sheibani-Tezerji , Alexandra Breuer, Anne Luzius, Marlene Jentzsch, Robert Häsler, Susanne Billmann-Born, Olga Will, Simone Lipinski, Richa
(2016)
18. Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation
Cell Reports
accepted, more information soon:
Chlamydia trachomatis as the cause of infectious infertility: acute, repetitive or persistent long-term infection?
Schuchardt L., Rupp J.
(2016)
Chlamydia trachomatis as the cause of infectious infertility: acute, repetitive or persistent long-term infection?
Current Topics in Microbiology and Immunology
02 July:
Phosphatidylserine exposure is required for ADAM17 sheddase function
Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K
(2016)
Phosphatidylserine exposure is required for ADAM17 sheddase function
Nature Communications
May 10;7:
article no 11523
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Dose Janina; Nebel, Almut; Piegholdt, Stefanie; Rimbach, Gerald; Huebbe, Patricia
(2016)
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Free Radical Biology and Medicine
April 26. pii: S0891-5849(16)30049-1. doi: 10.1016/j.freeradbiomed.2016.04.031. [Epub ahead of print]:
Stool frequency is associated with gut microbiota composition
Fatemeh Hadizadeh, Susanna Walter, Meriem Belheouane, Ferdinando Bonfiglio, Femke-Anouska Heinsen, Anna Andreasson
(2016)
Stool frequency is associated with gut microbiota composition
Gut
Apr 28, epub ahead of print:
Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease.
Gupta Y, Möller S, Witte M, Belheouane M, Sezin T, Hirose M, Vorobyev A, Niesar F, Bischof J, Ludwig R, Zillikens D, Sadik CD, Restle T, Häsler R, Baines JF, Ibrahim SM.
(2016)
Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease.
BMC Genomics
Feb 16;17(1):
112
Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T,Seeger K, Dahlke M, Rades D, Zillikens D, Ludwig RJ
(2015 )
Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
J Immunol
Sep 1;195(5):
1945-54
The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita
Sadeghi H, Gupta Y, Möller S, Samavedam UK, Behnen M, Kasprick A, Bieber K, Müller S, Kalies K, de Castro Marques A, Recke A, Schmidt E, Zillikens D, Laskay T, Mariani J, Ibrahim SM, Ludwig RJ
(2015 )
The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita
J Pathol
Sep;237(1):
111-22
Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.
Arlt A, Bharti R, Ilves I, Häsler R, Miettinen P, Paajanen H, Brunke G, Ellrichmann M, Rehman A, Hauser C, Egberts JH, Ott SJ, Schreiber S, Rosenstiel P, Herzig KH
(2013)
Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.
Innate Immun.
Jan 21(1):
30-41
Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection.
Jerchel S, Kaufhold I, Schuchardt L, Shima K, Rupp J
(2014)
Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection.
Front Cell Inf Microb
Apr 16:
4:34
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Tschurtschenthaler M, Wang J, Fricke C, Fritz TM, Niederreiter L, Adolph TE, Sarcevic E, Künzel S, Offner FA, Kalinke U, Baines JF, Tilg H, Kaser A
(2014)
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Gut
Dec;63(12):
1921-31
Paneth cells as a site of origin for intestinal inflammation
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Neves E, Glickman JN, Tschurtschenthaler M, ... Bharti R., ... Schreiber S., Rosenstiel P., Kaser A., Blumberg RS.
(2013)
Paneth cells as a site of origin for intestinal inflammation
Nature
Nov 14;503(7475):
272-6
Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control.
Yadav P(1), Freitag-Wolf S(1), Lieb W(2), Dempfle A(1), Krawczak M(3).
(2015)
Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control.
Hum Genet.
Oct;134(10)::
1117-25
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.
Düsterhöft S, Michalek M, Kordowski F1, Oldefest M, Sommer A1, Röseler J, Reiss K1, Grötzinger J, Lorenzen I.
(2015)
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.
Biochemistry
Sept 29, 54(38):
5791-801
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
Ute Fischer, Michael Forster, Anna Rinaldi, Thomas Risch, Stéphanie Sungalee, ….., Priyadarshini Kachroo, …., Arndt Borkhardt, Jean-Pierre Bourquin, Andre Franke, Jan O Korbel, Martin Stanulla & Marie-Laure Yaspo
(2015)
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
Nature Genetics
online July 27, doi:10.1038/ng.3362:
47(9):1020-9
Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters.
Vorobyev A, Ujiie H, Recke A, Buijsrogge JJ, Jonkman MF, Pas HH, Iwata H, Hashimoto T, Kim SC, Hoon Kim J, Groves R, Samavedam U, Gupta Y, Schmidt E, Zillikens D, Shimizu H, Ludwig RJ
(2015)
Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters.
J Invest Dermatol
Jun;135(6)::
1565-73
Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita
Iwata H, Pipi E, Möckel N, Sondermann P, Vorobyev A, van Beek N, Zillikens D, Ludwig RJ
(2015)
Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita
J Invest Dermatol
Mar;135(3):
916-9
The anti-atherogenic effect of fish oil in male mice is associated with a diminished release of endothelial ADAM17 and ADAM10 substrates
Nancy Speck, Corinna Brandsch, Nadine Schmidt, Narges Yazdekhasti, Frank Hirche, Ralph Lucius, Gerald Rimbach, Gabriele I. Stangl, Karina Reiss.
(2015)
The anti-atherogenic effect of fish oil in male mice is associated with a diminished release of endothelial ADAM17 and ADAM10 substrates
J Nutr.
Jun; 145(6)::
1218-26
Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.
Huebbe P1, Dose J, Schloesser A, Campbell G, Glüer CC, Gupta Y, Ibrahim S, Minihane AM, Baines JF, Nebel A, Rimbach G.
(2015)
Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.
Mol Nutr Food Res.
Feb;59 (2):
334-43
ptRNApred: computational identification and classification of post-transcriptional RNA
Gupta Y, Witte M, Möller S, Ludwig RJ, Restle T, Zillikens D and Ibrahim SM
(2014)
ptRNApred: computational identification and classification of post-transcriptional RNA
Published by Oxford University Press on behalf of Nucleic Acids Research
Dec 16;42(22):
e167
The role of linkage disequilibrium in case-only studies of gene-environment interactions.
Yadav P, Freitag-Wolf S, Lieb W, Krawczak M
(2015)
The role of linkage disequilibrium in case-only studies of gene-environment interactions.
Hum Genet.
2015 Jan., 134:
89-96
Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo
Recke A, Trog LM, Pas HH, Vorobyev A, Abadpour A, Jonkman MF, van Zandbergen G, Kauderer C, Zillikens D, Vidarsson G, Ludwig R
(2014)
Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo
J. Immunol.
Aug 14:
193(4):1600-8
Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease
Gupta Y, Möller S, Zillikens D, Boehncke W-H, Ibrahim SM and Ludwig RJ
(2013)
Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease
John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology
Aug; 22(8):
552-553