Florian Tran

Consolidated Researcher Details:

Institute:
Institute of Clinical Molecular Biology, University of Kiel & Department of Inner Medcine I, UKSH, Campus Kiel
Research Area:
Cell Biology
Website:
Institute of Clinical Molecular Biology, University of Kiel
Dr. med.
Florian Tran
f.tran [at] ikmb.uni-kiel.de
+49 (0) 431 / 500 - 22 220
Special / additional position within the RTG: Scholarship as doctoral researcher in medicine 2013/14, since 2014 associated, currently clinician scientist University Hospital Schleswig-Holstein, 2022/2023 Else Körner Memorial Fellowship
RTG-Project (Associated Scientist): Interactions between endoplasmic reticulum stress and cytokine signalling in epithelial regeneration in inflammatory bowel diseases
RTG-Project (Associated Scientist): A role of selective ER-phagy in intestinal homeostasis and inflammation?
Publications: Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories.
Publications: Low avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19.
Publications: Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
Publications: ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
Publications: ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING
Publications: Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation
Publications: Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair

Why this profession?

In 2010, I started to study human medicine at the University of Kiel. During this time I was faced with many diseases and signalling pathways that are partially or completely unknown; I started to get interested in gastrointestinal immunology, the development of colorectal cancer and the research of these mechanisms. Since deciphering these mechanisms is crucial for developing new treatment strategies I am glad that I can gain an insight in research work by starting an experimental doctoral thesis in Prof. Rosenstiel’s group at the Institute of Clinical Molecular Biology, University of Kiel.

Why RTG Genes, Environment and Inflammation?

The incidence of inflammatory bowel diseases (IBDs) is increasing in the general population and it is becoming more and more important to understand the pathomechanisms of chronic inflammation. Both genes and environment contribute to the development of IBDs. The same also applies for IBD-associated cancerogenesis, and I am particularly interested in their molecular bases.

The “Genes, Environment and Inflammation” Research Training Group provides a perfect platform for international and interdisciplinary exchange to discuss and realize projects like mine. As a medical doctoral researcher I am delighted to have joined a team of experienced scientists and ambitious doctoral candidates in which every member benefits from one another’s expertise, enabling me to gain a deeper insight into excellent research.