Jan Kuiper

Consolidated Researcher Details:

Institute of Clinical Molecular Biology, Kiel University
Research Area:
cellular functions of inflammatory bowel disease associated genes
Dr. rer. nat.
Jan Kuiper

Why this profession?

Soon after starting studying biology at Nijmegen University in the Netherlands I realized that biology is all about complexity, whether it is the interactions between species in an ecosystem or the numerous molecular processes within a single cell. During my specialization phase I choose medical biology and decided to do my MSc work on kinase (de)regulation in the Peter Maccallum Cancer Centre in Melbourne, Australia. 

After returning to the Netherlands I performed my PhD studies on the role of creatine kinase in cytoskeletal remodeling in neurons and macrophages. The ability of these cells to change their morphology dramatically in response to stimuli captivated me and led me to accept a postdoctoral position at the University of Toronto, where I investigated the contribution of GTPases Rac1 and Rac2 in chemotaxis of granulocytes. During a short stay at the Institute of Genetics in Cologne, I was involved in a project aimed to elucidate molecular mechanisms of necroptosis in the context of intestinal inflammation.

Currently, I work at the Institute of Clinical Molecular Biology IKMB in Kiel on various topics at the interface of cell biology and immunology, including autophagy and methylation. Most of my work revolves around unraveling cellular functions of inflammatory bowel disease associated genes, such as ATG16L1 and DLG5.

Why RTG Genes, Environment and Inflammation?

The focus of the RTG follows the current view on chronic inflammation as a multifactorial disease. This automatically implies a multidisciplinary approach, where scientists from different fields can contribute their respective expertise. The RTG provides an excellent platform to establish collaborations, share know-how and infrastructure and provide an exciting environment for students.