Janina Dose

Consolidated Researcher Details:

Institute:
Institute of Clinical Molecular Biology, University of Kiel
Research Area:
Molecular Biology, Nutrition and Dietetics, Nutritional Biochemistry
Dr. oec. troph.
Janina Dose
j.dose [at] ikmb.uni-kiel.de
+49 (0) 431 / 500 - 15 140

Why this profession?

Successful disputation:
4 November, 2015 (Institute of Human Nutrition and Food Sciences, University of Kiel

PostDoc position at the Institute of Clinical Molecular Biology,
Research Group "Longevity & Ancient DNA Research"

I hold a Master of Science (M.Sc.) degree in Nutritional Sciences. Prior to studying nutritional sciences at Kiel University, I completed a professional education as a lab technician. During my academic education I focused on genetics, nutrigenetics and genomics as I’ve always been interested in the complex interaction of dietary and genetic factors. I gained further practical experience in the course of voluntary internships at the German Institute of Human Nutrition (DIfE) in Potsdam-Rehbruecke and at the Lower Saxony State Office for Consumer Protection and Food Safety in Stade. I conducted my experimental Master's thesis in the research group of Prof. Rimbach at the Institute of Human Nutrition and Food Science at the University of Kiel. Here, I studied the effects of long-term dietary restriction on Nrf2-dependent and antioxidant gene expression and biomarkers of oxidative stress in mice.  

Currently, I am focusing on the impact of the APOE polymorphism on healthy ageing using gene targeted replacement mice as well as cell culture models, including macrophages and hepatocytes.

Why RTG Genes, Environment and Inflammation?

In the comprehensive research context of the RTG “Genes, Environment and Inflammation” I am studying the effects of the APOE genotype and environmental influences (i.e. diet) on age-related processes (i.e. inflammatory events). My future research activities are aimed towards a more detailed characterization of the APOE phenotype. I am presently looking at mitochondrial function, endoplasmic reticulum stress and lipid metabolism in relation to the APOE genotype.

Together with working in a comprehensive research context, being a member of this group means establishing new contacts, especially international ones. As a consequence of this additional scientific exchange I hope to receive new impulses from the group regarding my project. I will surely benefit from a high level of scientific and personal support and access to new technologies. Altogether, this will ensure that I successfully complete my PhD in three years.