Consolidated Researcher Details:
I am a Medical Doctor by training and a specialized Human Geneticist (Facharzt für Humangenetik). Besides teaching students in Human Genetics in my function as Full Professor and Chair of Human Genetics at the Christian-Albrechts-University and apart from administrative duties as Director of the Institute of Human Genetics at the UKSH, I spend much of my time counseling patients and signing out clinical diagnostics. Thus, my research is also very much patient-centered, aiming at understanding the mechanisms of disease predisposition and manifestation with the ultimate goal of bringing the results back to the bedsite. Dealing with genetic and epigenetic mechanisms my disease focuses are on cancer, inflammation, developmental diseases and imprinting disorders. My special interest is in somatic genetic and epigenetic changes, i.e. genetic changes acquired during life. Besides disease- and patient-oriented research, my group has participated in and is still contributing to huge international efforts in the field of human genetics, including the Human Genome Project, the International Cancer Genome Consortium (ICGC) and the International Human Epigenome Consortium (IHEC). Among others, I am coordinator of one of the German contributions to the ICGC, the ICGC MMML-Seq Project on Germinal-Center derived B-Cell Lymphomas.
As outlined above, I have a special interest in somatic genetic and epigenetic changes and how these affect health and disease. The RTG integrates questions on genetic susceptibility and the environmental mechanisms leading to disease manifestation via epigenetic means. Moreover, the questions addressed fit well with my interests in normal and neoplastic immunology. With the special expertise that my group has in clinical, constitutional and somatic genetics as well in epigenetics, I would like to support young scientist in their training and prepare and mentor them for their future career.