Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

Title of publication: 

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice

Authors: 

Konrad Aden, Kareen Bartsch, Joseph Dahl, Martin A M Reijns, Daniela Esser, Raheleh Sheibani-Tezerji , Anupam Sinha , Felix Wottawa, Go Ito, Neha Mishra, Katharina Knittler, Adam Burkholder, Lina Welz, Johan van Es, Florian Tran, Simone Lipinski, Nassim Kakavand, Christine Boeger, Ralph Lucius, Witigo von Schoenfels, Clemens Schafmayer , Lennart Lenk, Athena Chalaris, Hans Clevers, Christoph Röcken, Christoph Kaleta, Stefan Rose-John, Stefan Schreiber, Thomas Kunkel, Björn Rabe, Philip Rosenstiel

Year of Publication: 

2019

medium resp. publishing house / place: 

Gastroenterology

edition / issue: 

156(1)

Pages: 

145-159.e19

related to project: 

Interactions between endoplasmic reticulum stress and cytokine signalling in epithelial regeneration in inflammatory bowel diseases
Role of ATG16L1 in coordinating DNA damage induced inflammation and tumorigenesis in the intestinal epithelium
Endoplasmic reticulum stress in IBD – key regulator of innate immune signalling?
Role of the ER stress protein XBP-1 in coordinating DNA damage induced inflammation and tumorigenesis in the intestinal epithelium

Pubmed: 

Pubmed - PMID 30273559