On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3

Title of publication: 

On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3

Authors: 

Janina Dose, Anke Schloesser, Guillermo G. Torres, Geetha Venkatesh, Robert Häsler, Friederike Flachsbart, Wolfgang Lieb, Almut Nebel, Gerald Rimbach, Patricia Huebbe

Year of Publication: 

2018

medium resp. publishing house / place: 

J Allergy Clin Immunol. 2018 Jun 18. [Epub ahead of print]

related to project: 

Capsule summary

Under conditions reflecting the Western lifestyle, APOE ε4 vs. APOE ε3 may be associated with a lower expression of markers important in innate immune activation. The results encourage further investigations into the role of the APOE genotype in metabolic diseases associated with chronic inflammation.