Publications

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer
Lena Reinhold, Andreas Möllering, Sönke Wallis, Emanuel Palade, Kathrin Schäfer, Daniel Drömann, Jan Rupp, Simon Graspeuntner, Klaus Dalhoff
(2020)
Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer
Microorganisms
2020 May 26:
8(6):794
Identification of disease-associated traits and clonotypes in the T-cell receptor repertoire of monozygotic twins affected by inflammatory bowel diseases.
Rosati E, Pogorelyy MV, Dowds CM, Moller FT, Sorensen SB, Lebedev YB, Frey N, Schreiber S, Spehlmann ME, Andersen V, Franke A.
(2020)
Identification of disease-associated traits and clonotypes in the T-cell receptor repertoire of monozygotic twins affected by inflammatory bowel diseases.
J Crohns Colitis
2020 Jul. 9:
14(6):778-790
Genomewide Association Study of Severe Covid-19 With Respiratory Failure
D Ellinghaus, F Degenhardt, L Bujanda, M Buti, A Albillos, P Invernizzi, J Fernández, D Prati, G Baselli, R Asselta, M M Grimsrud, C Milani, F Aziz, J Kässens, S May, M Wendorff, L Wienbrandt, F Uellendahl-Werth, T Zheng, X Yi, R de Pablo, A G Chercoles, A Palom, A-E Garcia-Fernandez, F Rodriguez-Frias, A Zanella, A Bandera, A Protti, A Aghemo, A Lleo, A Biondi, A Caballero-Garralda, A Gori, A Tanck, A Carreras Nolla, A Latiano, A Ludovica Fracanzani, A Peschuck, A Julià, A Pesenti, A Voza, D Jiménez, B Mateos, B Nafria Jimenez, C Quereda, C Paccapelo, C Gassner, C Angelini, C Cea, A Solier, D Pestaña, E Muñiz-Diaz, E Sandoval, E M Paraboschi, E Navas, F García Sánchez, F Ceriotti, F Martinelli-Boneschi, F Peyvandi, F Blasi, L Téllez, A Blanco-Grau, G Hemmrich-Stanisak, G Grasselli, G Costantino, G Cardamone, G Foti, S Aneli, H Kurihara, H ElAbd, I My, I Galván-Femenia, J Martín, J Erdmann, J Ferrusquía-Acosta, K Garcia-Etxebarria, L Izquierdo-Sanchez, L R Bettini, L Sumoy, L Terranova, L Moreira, L Santoro, L Scudeller, F Mesonero, L Roade, M C Rühlemann, M Schaefer, M Carrabba, M Riveiro-Barciela, M E Figuera Basso, M G Valsecchi, M Hernandez-Tejero, M Acosta-Herrera, M D'Angiò, M Baldini, M Cazzaniga, M Schulzky, M Cecconi, M Wittig, M Ciccarelli, M Rodríguez-Gandía, M Bocciolone, M Miozzo, N Montano, N Braun, N Sacchi, N Martínez, O Özer, O Palmieri, P Faverio, P Preatoni, P Bonfanti, P Omodei, P Tentorio, P Castro, P M Rodrigues, A Blandino Ortiz, R de Cid, R Ferrer, R Gualtierotti, R Nieto, S Goerg, S Badalamenti, S Marsal, G Matullo, S Pelusi, S Juzenas, S Aliberti, V Monzani, V Moreno, T Wesse, T L Lenz, T Pumarola, V Rimoldi, S Bosari, W Albrecht, W Peter, M Romero-Gómez, M D'Amato, S Duga, J M Banales, J R Hov, T Folseraas, L Valenti, A Franke, T H Karlsen, Severe Covid-19 GWAS Group
(2020)
Genomewide Association Study of Severe Covid-19 With Respiratory Failure
N Engl J Med .
2020 Jun 17:
Online ahead of print.
Amino acid encoding for deep learning applications
Hesham ElAbd, Yana Bromberg, Adrienne Hoarfrost, Tobias Lenz, Andre Franke, Mareike Wendorff
(2020)
Amino acid encoding for deep learning applications
BMC Bioinformatics
2020 Jun 9:
21(1):235
Construction and Benchmarking of a Multi-Ethnic Reference Panel for the Imputation of HLA Class I and II Alleles
Frauke Degenhardt, Mareike Wendorff, Michael Wittig, Eva Ellinghaus, Lisa W Datta, John Schembri, Siew C Ng, Elisa Rosati, Matthias Hübenthal, David Ellinghaus, Eun Suk Jung, Wolfgang Lieb, Shifteh Abedian, Reza Malekzadeh, Jae Hee Cheon, Pierre Ellul, Ajit Sood, Vandana Midha, B K Thelma, Sunny H Wong, Stefan Schreiber, Keiko Yamazaki, Michiaki Kubo, Gabrielle Boucher, John D Rioux, Tobias L Lenz, Steven R Brant, Andre Franke
(2019 )
Construction and Benchmarking of a Multi-Ethnic Reference Panel for the Imputation of HLA Class I and II Alleles
Hum Mol Genet .
2019 Jun 15:
28(12):2078-2092
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P
(2018)
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Genome Med.
13 / Apr 2018:
27
Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study
Schulz J, Knappe C, Graetz C, Mewes L, Türk K1, Black AK, Lieb W, Schäfer AS, Fawzy El-Sayed KM, Dörfer CE, Schreiber S, Laudes M, Schulte DM
(2019)
Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study
J Clin Periodontol.j
May 2019; Epub 22 / Apr 2019:
522-528
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B; European Scleroderma Group (...Riemekasten G et al), Proudman S, Stevens W, Nikpour M; Australian Scleroderma Interest Group (ASIG), Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J
(2019)
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
Nat Commun.
31 / Oct 2019:
4955
Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease
Zeissig S, Rosati E, Dowds CM, Aden K, Bethge J, Schulte B, Pan WH, Mishra N, Zuhayra M, Marx M, Paulsen M, Strigli A, Conrad C, Schuldt D, Sinha A, Ebsen H, Kornell SC, Nikolaus S, Arlt A, Kabelitz D, Ellrichmann M, Lützen U, Rosenstiel PC, Franke A, Schreiber S
(2018)
Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease
Gut.
Jan 2019; Epub 5 / May 2018 :
25-39
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING
Aden K1,2, Tran F1,2, Ito G1,3, Sheibani-Tezerji R1, Lipinski S1, Kuiper JW1, Tschurtschenthaler M4,5, Saveljeva S5, Bhattacharyya J5, Häsler R1, Bartsch K6, Luzius A1, Jentzsch M1, Falk-Paulsen M1, Stengel ST1, Welz L1, Schwarzer R7, Rabe B6, Barchet W8, Krautwald S9, Hartmann G8, Pasparakis M7, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P
(2018)
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING
J Exp Med.
5 / Nov 2018; Epub 25 / Sep 2018:
2868-2886
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP
(2015)
The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
J Biol Chem.
20 / Mar 2015; Epub 20 / Jan 2015:
7416-25
Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation
Piegholdt S, Pallauf K, Esatbeyoglu T, Speck N, Reiss K, Ruddigkeit L, Stocker A, Huebbe P, Rimbach G
(2014)
Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation
Free Radic Biol Med.
May 2014; Epub 12 / Mar 2014:
255-64
Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers
Kordowski F, Kolarova J, Schafmayer C, Buch S, Goldmann T, Marwitz S, Kugler C, Scheufele S, Gassling V, Németh CG, Brosch M, Hampe J, Lucius R, Röder C, Kalthoff H, Siebert R, Ammerpohl O, Reiss K
(2018)
Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers
BMC Cancer.
6 / Aug 2018:
796
Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts
Belheouane M, Gupta Y, Künzel S, Ibrahim S, Baines JF
(2017)
Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts
Microbiome.
6 / Jun 2017:
59
The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita
Sadeghi H, Gupta Y, Möller S, Samavedam UK, Behnen M, Kasprick A, Bieber K, Müller S, Kalies K, de Castro Marques A, Recke A, Schmidt E, Zillikens D, Laskay T, Mariani J, Ibrahim SM, Ludwig RJ
(2015)
The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita
J Pathol.
Sep 2015; Epub 15 / Jun 2015:
111-22
Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T, Seeger K, Dahlke M, Rades D, Zillikens D, Ludwig RJ
(2015)
Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita
J Immunol.
1 / Sep 2015; Epub 22 / Jul 2015:
1945-54
Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
Vorobyev A, Ujiie H, Recke A, Buijsrogge JJA, Jonkman MF, Pas HH, Iwata H, Hashimoto T, Kim SC, Hoon Kim J, Groves R, Samavedam U, Gupta Y, Schmidt E, Zillikens D, Shimizu H, Ludwig RJ
(2015)
Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters
J Invest Dermatol.
Jun 2015; Epub 17 / Feb 2015:
1565-1573
Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita
Iwata H, Pipi E, Möckel N, Sondermann P, Vorobyev A, van Beek N, Zillikens D, Ludwig RJ
(2014)
Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita
J Invest Dermatol.
Mar 2015; Epub 20 / Oct 2014:
916-919
Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections
Loeper N, Graspeuntner S, Ledig S, Kaufhold I, Hoellen F, Schiefer A, Henrichfreise B, Pfarr K, Hoerauf A, Shima K, Rupp J
(2019)
Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections
Front Microbiol.
7 / May 2019:
943
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line
Vorobyev A, Gupta Y, Sezin T, Koga H, Bartsch Y C, Belheouane M, Künzel S, Sina C, Schilf P, Körber-Ahrens H, Beltsiou F, Ernst A L, Khil’chenko S, Al-Aasam H, Manz R A, Diehl S, Steinhaus M, Jascholt J, Kouki P, Boehncke W-H, Mayadas T N, Zillikens D, Sadik C D, Nishi H, Ehlers M, Möller S, Bieber K, Baines J F, Ibrahim S M & Ludwig R J
(2019)
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line
Nat Commun.
10 / Sep 2019:
4097
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
K. Aden, F. Tran, G. Ito, R. Sheibani-Tezerji, S. Lipinski, J. W. Kuiper, M. Tschurtschenthaler, S. Saveljeva, P. Bhattacharyya, R. Häsler, K. Bartsch, A. Luzius, M. Jentzsch, M. Falk-Paulsen, S. T. Stengel, L. Welz, R. Schwarzer, B. Rabe, W. Barchet, S. Krautwald, G. Hartmann, M. Pasparakis, R.S. Blumberg, S. Schreiber, A. Kaser, P. Rosenstiel
(2018)
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
Journal of experimental Medicine
2018 Sep 25:
Role of wnt5a in metabolic inflammation in humans
Relling I, Akcay G, Fangmann D, Knappe C, Schulte DM, Hartmann K, Müller N, Türk K, Dempfle A, Franke A, Schreiber S, Laudes M
(2018)
Role of wnt5a in metabolic inflammation in humans
J Clin Endocrinol Metab.
2018 Aug 20. [Epub ahead of print]:
Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome
Bonfiglio F, Zheng T, Garcia-Etxebarria K, Hadizadeh F, Bujanda L, Bresso F, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Latiano A, Hübenthal M, Thijs V, Netea MG, Jonkers D, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, Zhernakova A, D'Amato M
(2018)
Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome
Gastroenterology
Jul, Epub 2018 Apr 5:
168-179
Faecal microbiota composition associates with abdominal pain in the general population
Hadizadeh F, Bonfiglio F, Belheouane M, Vallier M, Sauer S, Bang C, Bujanda L, Andreasson A, Agreus L, Engstrand L, Talley NJ, Rafter J, Baines JF, Walter S, Franke A, D'Amato M
(2018)
Faecal microbiota composition associates with abdominal pain in the general population
Gut
Apr, Epub 2017 Aug 1:
778-779
Effective inhibition of rifampin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA-polymerase inhibitor Corallopyronin A
Kensuke Shimaa, Svea Ledig, Nathalie Loeper, Andrea Schieferd, Kenneth Pfarre, Achim Hoerauf, Simon Graspeuntner, Jan Rupp
(2018)
Effective inhibition of rifampin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA-polymerase inhibitor Corallopyronin A
International Journal of Antimicrobial Agents, Available online 6 August 2018
Selection of validated hypervariable regions is crucial in 16S-based microbiota studies of the female genital tract
Simon Graspeuntner, Nathalie Loeper, Sven Künzel, John F. Baines & Jan Rupp
(2018)
Selection of validated hypervariable regions is crucial in 16S-based microbiota studies of the female genital tract
Nature, Scientific Reports. volume 8, article number: 9678 (2018)
On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3
Janina Dose, Anke Schloesser, Guillermo G. Torres, Geetha Venkatesh, Robert Häsler, Friederike Flachsbart, Wolfgang Lieb, Almut Nebel, Gerald Rimbach, Patricia Huebbe
(2018)
On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3
J Allergy Clin Immunol. 2018 Jun 18. [Epub ahead of print]
Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease
Nathalie Loeper, Simon Graspeuntner, Jan Rupp
(2018)
Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease
Microbes and Infection
doi: 10.1016/j.micinf.2018.02.003:
in press, accepted manuscript
Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility
Simon Graspeuntner, Michael K. Bohlmann, Kathrin Gillmann, Runa Speer, Sven Kuenzel, Heike Mark, Friederike Hoellen, Reinhard Lettau, Georg Griesinger, Inke R. König, John F. Baines, Jan Rupp
(2018)
Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility
PLOS Biology
Jan. 9:
https://doi.org/10.1371/journal.pone.0191047
Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells
Sezin T, Vorobyev A, Sadik C, Zillikens D, Gupta Y, Ludwig R
(2018)
Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells
Front. Immunol.
17. January:
ePub 17. January 2018
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
Henström M, Diekmann L, Bonfiglio F, Hadizadeh F, Kuech EM, von Köckritz-Blickwede M, Thingholm LB, Zheng T, Assadi G, Dierks C, Heine M, Philipp U, Distl O, Money ME, Belheouane M, Heinsen FA, Rafter J, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Walter S, Simrén M, Karling P, Ohlsson B, Schmidt PT, Lindberg G, Dlugosz A, Agreus L, Andreasson A, Mayer E, Baines JF, Engstrand L, Portincasa P, Bellini M, Stanghellini V, Barbara G, Chang L, Camilleri M, Franke A, Naim HY, D'Amato M
(2016 )
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
Gut
Nov 21, epub ahead of print:
A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
Jankipersadsing SA, Hadizadeh F, Bonder MJ, Tigchelaar EF, Deelen P, Fu J, Andreasson A, Agreus L, Walter S, Wijmenga C, Hysi P, D'Amato M, Zhernakova A.
(2017)
A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency
Gut
April, epub 2016 Jul 29:
756-758
Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans
Fangmann D, Theismann EM, Türk K, Schulte DM, Relling I, Hartmann K, Keppler JK, Knipp JR, Rehman A, Heinsen FA, Franke A, Lenk L, Freitag-Wolf S, Appel E, Gorb S, Brenner C, Seegert D, Waetzig GH, Rosenstiel P, Schreiber S, Schwarz K, Laudes M.
(2017)
Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans
Diabetes Care
epub ahead of print :
Identification and characterization of two functional variants in the human longevity gene FOXO3
Flachsbart F, Dose J, Gentschew L, Geismann C, Caliebe A, Knecht C, Nygaard M, Badarinarayan N, ElSharawy A, May S, Luzius A, Torres GG, Jentzsch M, Forster M, Häesler R, Pallauf K, Lieb W, Derbois C, Galan P, Drichel D, Arlt A, Andreas Till A, Krause-Kyora B, Rimbach G, Blanché H, Deleuze J-F, Christiansen L, Christensen K, Nothnagel M, Rosenstiel P, Schreiber S, Franke A, Sebens S, Nebel A.
(2017)
Identification and characterization of two functional variants in the human longevity gene FOXO3
nature
Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.
Pankaj Yadav,* David Ellinghaus,* Gaëlle Rémy, Sandra Freitag-Wolf, Anabelle Cesaro, Frauke Degenhardt, Gabrielle Boucher, Myriam Delacre, The International IBD Genetics Consortium (IIBDGC), Laurent Peyrin-Biroulet, Muriel Pichavant, John D Rioux, Philippe Gosset, Andre Franke, L. Philip Schumm, Michael Krawczak, Mathias Chamaillard, Astrid Dempfle, and Vibeke Andersen
(2017)
Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.
Gastro
153(2):
550-565
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Giles DA, Moreno-Fernandez ME, Stankiewicz TE Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.
(2017)
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Nat Med.
23(7):
829-838
Impact of micro-environmental changes on respiratory tract infections with intracellular bacteria.
Shima K, Coopmeiners J, Graspeuntner S, Dalhoff K, Rupp J.
(2016)
Impact of micro-environmental changes on respiratory tract infections with intracellular bacteria.
FEBS Lett.
Nov/590(21):
3887-3904
Overview of methodologies for T-cell receptor repertoire analysis.
Rosati, E., Dowds, C.M., Liaskou, E., Henriksen, E.K.K., Karlsen, T.H., Franke, A.
(2017)
Overview of methodologies for T-cell receptor repertoire analysis.
BMC Biotechnology
Jul 10;17(1):61:
Hypothalamic Inflammation in Human Obesity is Mediated by Environmental and Genetic Factors.
Kreutzer C, Peters S, Schulte DM, Fangmann D, Türk K, Wolff S, van Eimeren T, Ahrens M, Beckmann J, Schafmayer C, Becker T, Kerby T, Rohr A, Riedel C, Heinsen FA, Degenhardt F, Franke A, Rosenstiel P, Zubek N, Henning C, Freitag-Wolf S, Dempfle A, Psilopanagioti A, Petrou-Papadaki H, Lenk L, Jansen O, Schreiber S, Laudes M
(2017)
Hypothalamic Inflammation in Human Obesity is Mediated by Environmental and Genetic Factors.
Diabetes
epub ahead of print:
Quantitative Trait Locus Analysis Implicates CD4+/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
Bischof J., Müller S., Borufka L., Asghari F., Möller S., Holzhüter SA., Nizze H., Ibrahim SM., Jaster R.
(2015)
Quantitative Trait Locus Analysis Implicates CD4+/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
PLoS One
Sept 1:
10(9)
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB3, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.
(2017)
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.
J. Exp. Med.
Jan 12:
epub ahead of print
TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M
Henström M, Hadizadeh F, Beyder A, Bonfiglio F, Zheng T, Assadi G, Rafter J, Bujanda L, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT7, Karling P, Ohlsson B, Talley NJ, Simren M, Walter S, Wouters M, Farrugia G, D'Amato M.
(2016)
TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M
Gut
14 Dec.:
epub ahead of print
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D'Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A.
(2016)
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Nat Genet.
Nov;48(11):
1396-1406
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
Aden K, Breuer A, Geese H, Tran F, Sommer J, Waetzig G, Reinheimer T, Schreiber S, Rose-John S, Scheller J, Rosenstiel P, Rehman A
(2016)
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
Oncogenesis
Nov 21:
5(11):e270.
bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data
Bischof J, Ibrahim S.
(2016)
bcRep: R Package for Comprehensive Analysis of B Cell Receptor Repertoire Data
PLoS One
Aug 23;11(8):
:e0161569
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Tschurtschenthaler M, Kachroo P, Heinsen FA, Adolph TE, Rühlemann MC, Klughammer J, Offner FA, Ammerpohl O, Krueger F, Smallwood S, Szymczak S, Kaser A, Franke A.
(2016)
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Sci Rep.
6 / Aug 19:
31640
APOE gentotype and stress response – a mini review
Dose j, Huebbe P, Nebel A, Rimbach G.
(2016)
APOE gentotype and stress response – a mini review
Lipids in Health and Disease
Jul 25:
15:121
Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation
Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher b, Chamaillard M, Kaser A, Rosenstiel P.
(2016)
Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation
Cell Reports
accepted, more information soon:
Chlamydia trachomatis as the cause of infectious infertility: acute, repetitive or persistent long-term infection?
Schuchardt L., Rupp J.
(2016)
Chlamydia trachomatis as the cause of infectious infertility: acute, repetitive or persistent long-term infection?
Current Topics in Microbiology and Immunology
02 July:
Phosphatidylserine exposure is required for ADAM17 sheddase function
Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K
(2016)
Phosphatidylserine exposure is required for ADAM17 sheddase function
Nature Communications
May 10;7:
article no 11523
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Dose J, Nebel A, Piegholdt S, Rimbach G, Huebbe P
(2016)
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Free Radical Biology and Medicine
April 26. pii: S0891-5849(16)30049-1. doi: 10.1016/j.freeradbiomed.2016.04.031. [Epub ahead of print]:
Stool frequency is associated with gut microbiota composition
Hadizadeh F, Walter S, Belheouane M, Bonfiglio F, Heinsen FA, Andreasson A
(2016)
Stool frequency is associated with gut microbiota composition
Gut
Apr 28, epub ahead of print:
Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease.
Gupta Y, Möller S, Witte M, Belheouane M, Sezin T, Hirose M, Vorobyev A, Niesar F, Bischof J, Ludwig R, Zillikens D, Sadik CD, Restle T, Häsler R, Baines JF, Ibrahim SM.
(2016)
Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease.
BMC Genomics
Feb 16;17(1):
112
Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.
Arlt A, Bharti R, Ilves I, Häsler R, Miettinen P, Paajanen H, Brunke G, Ellrichmann M, Rehman A, Hauser C, Egberts JH, Ott SJ, Schreiber S, Rosenstiel P, Herzig KH
(2013)
Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.
Innate Immun.
Jan 21(1):
30-41
Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection.
Jerchel S, Kaufhold I, Schuchardt L, Shima K, Rupp J
(2014)
Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection.
Front Cell Inf Microb
Apr 16:
4:34
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Tschurtschenthaler M, Wang J, Fricke C, Fritz TM, Niederreiter L, Adolph TE, Sarcevic E, Künzel S, Offner FA, Kalinke U, Baines JF, Tilg H, Kaser A
(2014)
Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Gut
Dec;63(12):
1921-31
Paneth cells as a site of origin for intestinal inflammation
Adolph TE1, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.
(2013)
Paneth cells as a site of origin for intestinal inflammation
Nature
Nov 14;503(7475):
272-6
Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control.
Yadav P(1), Freitag-Wolf S(1), Lieb W(2), Dempfle A(1), Krawczak M(3).
(2015)
Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control.
Hum Genet.
Oct;134(10)::
1117-25
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.
Düsterhöft S, Michalek M, Kordowski F1, Oldefest M, Sommer A1, Röseler J, Reiss K1, Grötzinger J, Lorenzen I.
(2015)
Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.
Biochemistry
Sept 29, 54(38):
5791-801
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz A, Sultan M, Tchinda J, Worth C, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay M, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas O, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll J, Hornhardt S, Husemann P, Kachroo P, Kratz C, Te Kronnie G, Marovca B, Niggli F, McHardy A, Moorman A, Panzer-Grümayer R, Petersen B, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, von der Weid N, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel J, Stanulla M, Yaspo M.
(2015)
Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
Nature Genetics
online July 27, doi:10.1038/ng.3362:
47(9):1020-9
The anti-atherogenic effect of fish oil in male mice is associated with a diminished release of endothelial ADAM17 and ADAM10 substrates
Speck N, Brandsch C, Schmidt N, Yazdekhasti N, Hirche F, Lucius R, Rimbach G, Stangl G, Reiss K.
(2015)
The anti-atherogenic effect of fish oil in male mice is associated with a diminished release of endothelial ADAM17 and ADAM10 substrates
J Nutr.
Jun; 145(6)::
1218-26
Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.
Huebbe P1, Dose J, Schloesser A, Campbell G, Glüer CC, Gupta Y, Ibrahim S, Minihane AM, Baines JF, Nebel A, Rimbach G.
(2015)
Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.
Mol Nutr Food Res.
Feb;59 (2):
334-43
ptRNApred: computational identification and classification of post-transcriptional RNA
Gupta Y, Witte M, Möller S, Ludwig RJ, Restle T, Zillikens D and Ibrahim SM
(2014)
ptRNApred: computational identification and classification of post-transcriptional RNA
Published by Oxford University Press on behalf of Nucleic Acids Research
Dec 16;42(22):
e167
The role of linkage disequilibrium in case-only studies of gene-environment interactions.
Yadav P, Freitag-Wolf S, Lieb W, Krawczak M
(2015)
The role of linkage disequilibrium in case-only studies of gene-environment interactions.
Hum Genet.
2015 Jan., 134:
89-96
Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo
Recke A, Trog LM, Pas HH, Vorobyev A, Abadpour A, Jonkman MF, van Zandbergen G, Kauderer C, Zillikens D, Vidarsson G, Ludwig R
(2014)
Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo
J. Immunol.
Aug 14:
193(4):1600-8
Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease
Gupta Y, Möller S, Zillikens D, Boehncke W-H, Ibrahim SM and Ludwig RJ
(2013)
Genetic control of psoriasis is relatively distinct from that of metabolic syndrome and coronary artery disease
John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology
Aug; 22(8):
552-553