Publications

Genotype imputation in case-only studies of gene-environment interaction: validity and power

Milda Aleknonytė-Resch, Silke Szymczak, Sandra Freitag-Wolf, Astrid Dempfle, Michael Krawczak

(2021)

Genotype imputation in case-only studies of gene-environment interaction: validity and power

Hum Genet.

140(8):

1217-1228

Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis

Lina Welz, Nassim Kakavand, Xiang Hang, Georg Laue, Go Ito, Miguel Gomes Silva, Christina Plattner, Neha Mishra, Felicitas Tengen, Christoph Ogris, Moritz Jesinghaus, Felix Wottawa, Philipp Arnold, Leena Kaikkonen, Stefanie Stengel, Florian Tran, Saumya Das, Arthur Kaser, Zlatko Trajanoski, Richard Blumberg, Christoph Roecken, Dieter Saur, Markus Tschurtschenthaler, Stefan Schreiber, Philip Rosenstiel, Konrad Aden

(2021 )

Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis

Gastroenterology

S0016-5085(21)03606-4:

Online ahead of print.

Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data

Hesham ElAbd, Frauke Degenhardt, Tomas Koudelka, Ann-Kristin Kamps, Andreas Tholey, Petra Bacher, Tobias L Lenz, Andre Franke, Mareike Wendorff

(2021)

Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data

BMC Bioinformatics

Aug 17:

22(1)

The role of cGAS/STING in intestinal immunity

Felix Wottawa, Dora Bordoni, Nathan Baran, Philip Rosenstiel, Konrad Aden

(2021)

The role of cGAS/STING in intestinal immunity

Eur J Immunol

Online ahead of print. :

Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice

Martin Veit, Björn Ahrens, Jana Seidel, Anselm Sommer, Sucharit Bhakdi, Karina Reiss

(2019)

Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice

Life Sci Alliance

Aug 27;2(5) / Print 2019 Oct. :

e201900430

Case-only analysis of gene-gene interactions in inflammatory bowel disease

Milda Aleknonytė-Resch, Sandra Freitag-Wolf, International Inflammatory Bowel Disease Genetics Consortium; Stefan Schreiber, Michael Krawczak, Astrid Dempfle

(2020)

Case-only analysis of gene-gene interactions in inflammatory bowel disease

Scand J Gastroenterol .

Aug;55(8):

897-906

Low avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19.

Petra Bacher, Elisa Rosati, Daniela Esser, Gabriela Rios Martini, Carina Saggau, Esther Schiminsky, Justina Dargvainiene, Ina Schöder, Imke Wieters, Yascha Khodamoradi, Fabian Eberhardt, Maria J.G.T. Vehreschild, Holger Neb, Michael Sonntagbauer, Claudio Conrad, Florian Tran, Philip Rosenstiel, Robert Markewitz, Klaus-Peter Wandinger, Max Augustin, Jan Rybniker, Matthias Kochanek, Frank Leypoldt, Oliver A. Cornely, Philipp Koehler, Andre Franke, Alexander Scheffold.

(2020)

Low avidity CD4+ T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19.

Immunity

Nov.:

https://doi.org/10.1016/j.immuni.2020.11.016

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories.

Joana P. Bernardes*, Neha Mishra*, Florian Tran*, Thomas Bahmer, Lena Best,Johanna I. Blase, Dora Bordoni, Jeanette Franzenburg, Ulf Geisen, JonathanJosephs-Spaulding, Philipp Köhler, Axel Künstner, Elisa Rosati, Anna C.Aschenbrenner, Petra Bacher, Nathan Baran, Teide Boysen, Burkhard Brandt, Niklas Bruse, Jonathan Dörr, Andreas Dräger, Gunnar Elke, David Ellinghaus, Julia Fischer, Michael Forster, Andre Franke, Sören Franzenburg, Norbert Frey, Anette Friedrichs, Janina Fuß, Andreas Glück, Jacob Hamm, Finn Hinrichsen, Marc P.Hoeppner, Simon Imm, Ralf Junker, Sina Kaiser, Ying H. Kan, Rainer Knoll, Christoph Lange, Georg Laue, Clemens Lier, Matthias Lindner, Georgios Marinos, Robert Markewitz, Jacob Nattermann, Rainer Noth, Peter Pickkers, Klaus F. Rabe, Alina Renz, Christoph Röcken, Jan Rupp, Annika Schaffarzyk, Alexander Scheffold, Jonas Schulte-Schrepping, Domagoj Schunck, Dirk Skowasch, Thomas Ulas, Klaus-Peter Wandinger, Michael Wittig, Johannes Zimmermann, Hauke Busch, Bimba F. Hoyer, Christoph Kaleta, Jan Heyckendorf, Matthijs Kox, Jan Rybniker, Stefan Schreiber,Joachim Schultze, Philip Rosenstiel, HCA Lung Bilogical Network and the Deutsche COVID-19 Omics Initiative (DeCOI).

(2020)

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories.

Immunity

Nov.:

doi.org/10.1016/j.immuni.2020.11.017

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer

Lena Reinhold, Andreas Möllering, Sönke Wallis, Emanuel Palade, Kathrin Schäfer, Daniel Drömann, Jan Rupp, Simon Graspeuntner, Klaus Dalhoff

(2020)

Dissimilarity of Airway and Lung Tissue Microbiota in Smokers undergoing Surgery for Lung Cancer

Microorganisms

2020 May 26:

8(6):794

Identification of disease-associated traits and clonotypes in the T-cell receptor repertoire of monozygotic twins affected by inflammatory bowel diseases.

Rosati E, Pogorelyy MV, Dowds CM, Moller FT, Sorensen SB, Lebedev YB, Frey N, Schreiber S, Spehlmann ME, Andersen V, Franke A.

(2020)

Identification of disease-associated traits and clonotypes in the T-cell receptor repertoire of monozygotic twins affected by inflammatory bowel diseases.

J Crohns Colitis

2020 Jul. 9:

14(6):778-790

Pubmed - PMID 31711184

Genomewide Association Study of Severe Covid-19 With Respiratory Failure

D Ellinghaus, F Degenhardt, L Bujanda, M Buti, A Albillos, P Invernizzi, J Fernández, D Prati, G Baselli, R Asselta, M M Grimsrud, C Milani, F Aziz, J Kässens, S May, M Wendorff, L Wienbrandt, F Uellendahl-Werth, T Zheng, X Yi, R de Pablo, A G Chercoles, A Palom, A-E Garcia-Fernandez, F Rodriguez-Frias, A Zanella, A Bandera, A Protti, A Aghemo, A Lleo, A Biondi, A Caballero-Garralda, A Gori, A Tanck, A Carreras Nolla, A Latiano, A Ludovica Fracanzani, A Peschuck, A Julià, A Pesenti, A Voza, D Jiménez, B Mateos, B Nafria Jimenez, C Quereda, C Paccapelo, C Gassner, C Angelini, C Cea, A Solier, D Pestaña, E Muñiz-Diaz, E Sandoval, E M Paraboschi, E Navas, F García Sánchez, F Ceriotti, F Martinelli-Boneschi, F Peyvandi, F Blasi, L Téllez, A Blanco-Grau, G Hemmrich-Stanisak, G Grasselli, G Costantino, G Cardamone, G Foti, S Aneli, H Kurihara, H ElAbd, I My, I Galván-Femenia, J Martín, J Erdmann, J Ferrusquía-Acosta, K Garcia-Etxebarria, L Izquierdo-Sanchez, L R Bettini, L Sumoy, L Terranova, L Moreira, L Santoro, L Scudeller, F Mesonero, L Roade, M C Rühlemann, M Schaefer, M Carrabba, M Riveiro-Barciela, M E Figuera Basso, M G Valsecchi, M Hernandez-Tejero, M Acosta-Herrera, M D'Angiò, M Baldini, M Cazzaniga, M Schulzky, M Cecconi, M Wittig, M Ciccarelli, M Rodríguez-Gandía, M Bocciolone, M Miozzo, N Montano, N Braun, N Sacchi, N Martínez, O Özer, O Palmieri, P Faverio, P Preatoni, P Bonfanti, P Omodei, P Tentorio, P Castro, P M Rodrigues, A Blandino Ortiz, R de Cid, R Ferrer, R Gualtierotti, R Nieto, S Goerg, S Badalamenti, S Marsal, G Matullo, S Pelusi, S Juzenas, S Aliberti, V Monzani, V Moreno, T Wesse, T L Lenz, T Pumarola, V Rimoldi, S Bosari, W Albrecht, W Peter, M Romero-Gómez, M D'Amato, S Duga, J M Banales, J R Hov, T Folseraas, L Valenti, A Franke, T H Karlsen, Severe Covid-19 GWAS Group

(2020)

Genomewide Association Study of Severe Covid-19 With Respiratory Failure

N Engl J Med .

2020 Jun 17:

Online ahead of print.

DOI: 10.1056/NEJMoa2020283

Amino acid encoding for deep learning applications

Hesham ElAbd, Yana Bromberg, Adrienne Hoarfrost, Tobias Lenz, Andre Franke, Mareike Wendorff

(2020)

Amino acid encoding for deep learning applications

BMC Bioinformatics

2020 Jun 9:

21(1):235

Construction and Benchmarking of a Multi-Ethnic Reference Panel for the Imputation of HLA Class I and II Alleles

Frauke Degenhardt, Mareike Wendorff, Michael Wittig, Eva Ellinghaus, Lisa W Datta, John Schembri, Siew C Ng, Elisa Rosati, Matthias Hübenthal, David Ellinghaus, Eun Suk Jung, Wolfgang Lieb, Shifteh Abedian, Reza Malekzadeh, Jae Hee Cheon, Pierre Ellul, Ajit Sood, Vandana Midha, B K Thelma, Sunny H Wong, Stefan Schreiber, Keiko Yamazaki, Michiaki Kubo, Gabrielle Boucher, John D Rioux, Tobias L Lenz, Steven R Brant, Andre Franke

(2019 )

Construction and Benchmarking of a Multi-Ethnic Reference Panel for the Imputation of HLA Class I and II Alleles

Hum Mol Genet .

2019 Jun 15:

28(12):2078-2092

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P

(2018)

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Genome Med.

13 / Apr 2018:

27

Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study

Schulz J, Knappe C, Graetz C, Mewes L, Türk K1, Black AK, Lieb W, Schäfer AS, Fawzy El-Sayed KM, Dörfer CE, Schreiber S, Laudes M, Schulte DM

(2019)

Secreted frizzled-related protein 5 serum levels in human periodontitis-A nested case-control study

J Clin Periodontol.j

May 2019; Epub 22 / Apr 2019:

522-528

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B; European Scleroderma Group (...Riemekasten G et al), Proudman S, Stevens W, Nikpour M; Australian Scleroderma Interest Group (ASIG), Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J

(2019)

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Nat Commun.

31 / Oct 2019:

4955

Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease

Zeissig S, Rosati E, Dowds CM, Aden K, Bethge J, Schulte B, Pan WH, Mishra N, Zuhayra M, Marx M, Paulsen M, Strigli A, Conrad C, Schuldt D, Sinha A, Ebsen H, Kornell SC, Nikolaus S, Arlt A, Kabelitz D, Ellrichmann M, Lützen U, Rosenstiel PC, Franke A, Schreiber S

(2018)

Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease

Gut.

Jan 2019; Epub 5 / May 2018 :

25-39

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

Aden K1,2, Tran F1,2, Ito G1,3, Sheibani-Tezerji R1, Lipinski S1, Kuiper JW1, Tschurtschenthaler M4,5, Saveljeva S5, Bhattacharyya J5, Häsler R1, Bartsch K6, Luzius A1, Jentzsch M1, Falk-Paulsen M1, Stengel ST1, Welz L1, Schwarzer R7, Rabe B6, Barchet W8, Krautwald S9, Hartmann G8, Pasparakis M7, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P

(2018)

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

J Exp Med.

5 / Nov 2018; Epub 25 / Sep 2018:

2868-2886

The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding

Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP

(2015)

The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding

J Biol Chem.

20 / Mar 2015; Epub 20 / Jan 2015:

7416-25

Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation

Piegholdt S, Pallauf K, Esatbeyoglu T, Speck N, Reiss K, Ruddigkeit L, Stocker A, Huebbe P, Rimbach G

(2014)

Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation

Free Radic Biol Med.

May 2014; Epub 12 / Mar 2014:

255-64

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers

Kordowski F, Kolarova J, Schafmayer C, Buch S, Goldmann T, Marwitz S, Kugler C, Scheufele S, Gassling V, Németh CG, Brosch M, Hampe J, Lucius R, Röder C, Kalthoff H, Siebert R, Ammerpohl O, Reiss K

(2018)

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers

BMC Cancer.

6 / Aug 2018:

796

Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts

Belheouane M, Gupta Y, Künzel S, Ibrahim S, Baines JF

(2017)

Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts

Microbiome.

6 / Jun 2017:

59

The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita

Sadeghi H, Gupta Y, Möller S, Samavedam UK, Behnen M, Kasprick A, Bieber K, Müller S, Kalies K, de Castro Marques A, Recke A, Schmidt E, Zillikens D, Laskay T, Mariani J, Ibrahim SM, Ludwig RJ

(2015)

The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita

J Pathol.

Sep 2015; Epub 15 / Jun 2015:

111-22

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T, Seeger K, Dahlke M, Rades D, Zillikens D, Ludwig RJ

(2015)

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

J Immunol.

1 / Sep 2015; Epub 22 / Jul 2015:

1945-54

Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters

Vorobyev A, Ujiie H, Recke A, Buijsrogge JJA, Jonkman MF, Pas HH, Iwata H, Hashimoto T, Kim SC, Hoon Kim J, Groves R, Samavedam U, Gupta Y, Schmidt E, Zillikens D, Shimizu H, Ludwig RJ

(2015)

Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters

J Invest Dermatol.

Jun 2015; Epub 17 / Feb 2015:

1565-1573

Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita

Iwata H, Pipi E, Möckel N, Sondermann P, Vorobyev A, van Beek N, Zillikens D, Ludwig RJ

(2014)

Recombinant soluble CD32 suppresses disease progression in experimental epidermolysis bullosa acquisita

J Invest Dermatol.

Mar 2015; Epub 20 / Oct 2014:

916-919

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections

Loeper N, Graspeuntner S, Ledig S, Kaufhold I, Hoellen F, Schiefer A, Henrichfreise B, Pfarr K, Hoerauf A, Shima K, Rupp J

(2019)

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections

Front Microbiol.

7 / May 2019:

943

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Vorobyev A, Gupta Y, Sezin T, Koga H, Bartsch Y C, Belheouane M, Künzel S, Sina C, Schilf P, Körber-Ahrens H, Beltsiou F, Ernst A L, Khil’chenko S, Al-Aasam H, Manz R A, Diehl S, Steinhaus M, Jascholt J, Kouki P, Boehncke W-H, Mayadas T N, Zillikens D, Sadik C D, Nishi H, Ehlers M, Möller S, Bieber K, Baines J F, Ibrahim S M & Ludwig R J

(2019)

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Nat Commun.

10 / Sep 2019:

4097

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

K. Aden, F. Tran, G. Ito, R. Sheibani-Tezerji, S. Lipinski, J. W. Kuiper, M. Tschurtschenthaler, S. Saveljeva, P. Bhattacharyya, R. Häsler, K. Bartsch, A. Luzius, M. Jentzsch, M. Falk-Paulsen, S. T. Stengel, L. Welz, R. Schwarzer, B. Rabe, W. Barchet, S. Krautwald, G. Hartmann, M. Pasparakis, R.S. Blumberg, S. Schreiber, A. Kaser, P. Rosenstiel

(2018)

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Journal of experimental Medicine

2018 Sep 25:

Role of wnt5a in metabolic inflammation in humans

Relling I, Akcay G, Fangmann D, Knappe C, Schulte DM, Hartmann K, Müller N, Türk K, Dempfle A, Franke A, Schreiber S, Laudes M

(2018)

Role of wnt5a in metabolic inflammation in humans

J Clin Endocrinol Metab.

2018 Aug 20. [Epub ahead of print]:

Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome

Bonfiglio F, Zheng T, Garcia-Etxebarria K, Hadizadeh F, Bujanda L, Bresso F, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Latiano A, Hübenthal M, Thijs V, Netea MG, Jonkers D, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, Zhernakova A, D'Amato M

(2018)

Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome

Gastroenterology

Jul, Epub 2018 Apr 5:

168-179

Faecal microbiota composition associates with abdominal pain in the general population

Hadizadeh F, Bonfiglio F, Belheouane M, Vallier M, Sauer S, Bang C, Bujanda L, Andreasson A, Agreus L, Engstrand L, Talley NJ, Rafter J, Baines JF, Walter S, Franke A, D'Amato M

(2018)

Faecal microbiota composition associates with abdominal pain in the general population

Gut

Apr, Epub 2017 Aug 1:

778-779

Effective inhibition of rifampin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA-polymerase inhibitor Corallopyronin A

Kensuke Shimaa, Svea Ledig, Nathalie Loeper, Andrea Schieferd, Kenneth Pfarre, Achim Hoerauf, Simon Graspeuntner, Jan Rupp

(2018)

Effective inhibition of rifampin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA-polymerase inhibitor Corallopyronin A

International Journal of Antimicrobial Agents, Available online 6 August 2018

Selection of validated hypervariable regions is crucial in 16S-based microbiota studies of the female genital tract

Simon Graspeuntner, Nathalie Loeper, Sven Künzel, John F. Baines & Jan Rupp

(2018)

Selection of validated hypervariable regions is crucial in 16S-based microbiota studies of the female genital tract

Nature, Scientific Reports. volume 8, article number: 9678 (2018)

On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3

Janina Dose, Anke Schloesser, Guillermo G. Torres, Geetha Venkatesh, Robert Häsler, Friederike Flachsbart, Wolfgang Lieb, Almut Nebel, Gerald Rimbach, Patricia Huebbe

(2018)

On a Western diet, APOE ε4 is associated with low innate immune sensing, but not APOE ε3

J Allergy Clin Immunol. 2018 Jun 18. [Epub ahead of print]

Pubmed - PMID 29928926

Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease

Nathalie Loeper, Simon Graspeuntner, Jan Rupp

(2018)

Microbiota changes impact on sexually transmitted infections and the development of pelvic inflammatory disease

Microbes and Infection

doi: 10.1016/j.micinf.2018.02.003:

in press, accepted manuscript

Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility

Simon Graspeuntner, Michael K. Bohlmann, Kathrin Gillmann, Runa Speer, Sven Kuenzel, Heike Mark, Friederike Hoellen, Reinhard Lettau, Georg Griesinger, Inke R. König, John F. Baines, Jan Rupp

(2018)

Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility

PLOS Biology

Jan. 9:

https://doi.org/10.1371/journal.pone.0191047

Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells

Sezin T, Vorobyev A, Sadik C, Zillikens D, Gupta Y, Ludwig R

(2018)

Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells

Front. Immunol.

17. January:

ePub 17. January 2018

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome

Henström M, Diekmann L, Bonfiglio F, Hadizadeh F, Kuech EM, von Köckritz-Blickwede M, Thingholm LB, Zheng T, Assadi G, Dierks C, Heine M, Philipp U, Distl O, Money ME, Belheouane M, Heinsen FA, Rafter J, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Walter S, Simrén M, Karling P, Ohlsson B, Schmidt PT, Lindberg G, Dlugosz A, Agreus L, Andreasson A, Mayer E, Baines JF, Engstrand L, Portincasa P, Bellini M, Stanghellini V, Barbara G, Chang L, Camilleri M, Franke A, Naim HY, D'Amato M

(2016 )

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome

Gut

Nov 21, epub ahead of print:

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency

Jankipersadsing SA, Hadizadeh F, Bonder MJ, Tigchelaar EF, Deelen P, Fu J, Andreasson A, Agreus L, Walter S, Wijmenga C, Hysi P, D'Amato M, Zhernakova A.

(2017)

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency

Gut

April, epub 2016 Jul 29:

756-758

Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans

Fangmann D, Theismann EM, Türk K, Schulte DM, Relling I, Hartmann K, Keppler JK, Knipp JR, Rehman A, Heinsen FA, Franke A, Lenk L, Freitag-Wolf S, Appel E, Gorb S, Brenner C, Seegert D, Waetzig GH, Rosenstiel P, Schreiber S, Schwarz K, Laudes M.

(2017)

Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans

Diabetes Care

epub ahead of print :

Pubmed - PMID 29212824

Identification and characterization of two functional variants in the human longevity gene FOXO3

Flachsbart F, Dose J, Gentschew L, Geismann C, Caliebe A, Knecht C, Nygaard M, Badarinarayan N, ElSharawy A, May S, Luzius A, Torres GG, Jentzsch M, Forster M, Häesler R, Pallauf K, Lieb W, Derbois C, Galan P, Drichel D, Arlt A, Andreas Till A, Krause-Kyora B, Rimbach G, Blanché H, Deleuze J-F, Christiansen L, Christensen K, Nothnagel M, Rosenstiel P, Schreiber S, Franke A, Sebens S, Nebel A.

(2017)

Identification and characterization of two functional variants in the human longevity gene FOXO3

nature

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.

Pankaj Yadav,* David Ellinghaus,* Gaëlle Rémy, Sandra Freitag-Wolf, Anabelle Cesaro, Frauke Degenhardt, Gabrielle Boucher, Myriam Delacre, The International IBD Genetics Consortium (IIBDGC), Laurent Peyrin-Biroulet, Muriel Pichavant, John D Rioux, Philippe Gosset, Andre Franke, L. Philip Schumm, Michael Krawczak, Mathias Chamaillard, Astrid Dempfle, and Vibeke Andersen

(2017)

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.

Gastro

153(2):

550-565

Pubmed - PMID 28506689

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

(2017)

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Nat Med.

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